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Deficiency of intracellular glutathione can worsen oxidative stress and accelerate cellular death in diseases such as Alzheimer disease, Parkinson disease, liver disease, cystic fibrosis, sickle cell anemia, HIV/AIDS and diabetes

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doi: 10.1038/s41419-018-0379-2 257 ShiY.LinS.StaatsK

22 If hematocrit creeps up, for example, which it sometimes does, its easily corrected with a dose adjustment or therapeutic phlebotomy (a medical treatment that removes specific amounts of blood to manage conditions like iron overload)