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Recent phase 3 clinical trials show that people taking the highest doses lost an average of 28.7% of their body weight over 68 weeks, which is about 71 pounds
both peptides scale together with every volume change
Severe or persistent side effectssuch as vomiting, severe constipation, or signs of pancreatitisrequire immediate provider contact and may warrant a delay in dose escalation or a switch to oral tirzepatide or a different GLP-1 agent
More than 15% body weight reduction is clinically relevant, resulting in metabolic health improvements, such as improved glycemia and remission of T2D 36
Kidney Disease: Improving Global Outcomes Work Group (KDIGO) 2022 clinical practice guideline for diabetes management in chronic kidney disease
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