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10.1080/09540105.2017.1306493 46 MoonesingheH.MackenzieH.VenterC.KilburnS.TurnerP.WeirK.et al (2016)

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[31] The absolute indications are a large goiter (especially when compressing the trachea), suspicious nodules or suspected cancer (to examine the thyroid pathologically), and people with ophthalmopathy, and additionally if it is the person's preferred method of treatment or if refusing to undergo radioactive iodine treatment

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The LKB1AMPK axis (an energy sensor) is activated by energy starvation through phosphorylation, directly initiating ULK1Atg13FIP200 complex formation, or through TSC1/2-dependent or -independent mTOR inhibition