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En rduisant l'activit de la tyrosinase, le glutathion diminue la quantit totale de mlanine synthtise par les mlanocytes, ce qui entrane progressivement un claircissement et une attnuation de la pigmentation cutane

Data availability The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request

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ADA rates with semaglutide are low, while tirzepatide showed ADA in a minority of patients without affecting its pharmacokinetics or efficacy

This is possibly due to overlapping anti-hyperglycemic mechanisms shared by both cagrilintide and semaglutide such as delay in gastric emptying and inhibition of postprandial glucagon secretion