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Going above 300 mg daily is rarely supported by hypertension trial data and increases the risk of GI side effects (nausea, diarrhea, appetite loss)
Orthopaedic surgery is uniquely sensitive to small shifts in perioperative risk, particularly in implant-based procedures where complications carry disproportionate consequences
Vitamin E is a particularly important antioxidant vitamin to prioritise in the diet after a course of Roaccutane
Potential redox cycling-based toxicity has been implicated with many compounds 7
Patients with even mid-range to high-range levels of vitamin B12 often still have a high MCV and high homocysteine (discussed below) and can benefit from vitamin B12 levels
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