Proper technique involves cleaning the injection site with alcohol, pinching the skin to create a fold, inserting the needle at a 45-90 degree angle, injecting slowly, and rotating injection sites to prevent irritation
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Am J Phys Heart Circ Phys 304:H1085H1093 Wu FT, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS (2010) VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model