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Although participants on semaglutide 2.4 mg had a significant reduction in SBP and DBP compared with placebo, in our ITT analysis, the adjusted mean difference in SBP fell short of statistical significance ( P = 0.059)
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Researchers debate how much of that loss is a normal, expected adjustment to carrying less body weight versus a change worth actively preventing
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Each receptor contributes distinct signaling characteristics: GLP-1 receptor activation modulates incretin signaling cascades and gastric motility pathways
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