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Thus, an understanding of the various disorders and substances that can contribute to oral and perioral pigmentation is essential for the appropriate evaluation, diagnosis, and management of the patient
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The 2021 meta-analysis found a relative risk of 3.66, but the 95% confidence interval stretches from 1.09 to 12.25
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Figure 5: Changes in the levels of A) IL-1-beta, B) TNF-alpha, and C) IL-10 in each of the four different experimental groups included in the first part of the study
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