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Starting at a low, non-therapeutic dose (2.5 mg) for four weeks before escalating allows for gradual acclimatization and significantly improves the overall tolerability of the drug
Zhang, H., Liao, X., Sparks, J
Z., Zheng, S
Some symptomslike fatigue or stomach sensitivitymay last longer but usually become manageable
The overlap matters because it means you could trigger the same discontinuation-level side effects at a lower nominal dose simply by injecting more frequently
Week one brings the strongest symptoms
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