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Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells

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doi: 10.3389/fimmu.2020.01748 51 DaiJ.WangY.WangH.GaoZ.WangY.FangM.et al

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The formation of gamma-glutamylcysteine is the rate-limiting reaction in GSH synthesis and is feedback inhibited by GSH itself, a mechanism responsible for the regulation of cellular GSH concentration

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