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Ng et al., Journal of Endocrinology found that AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue without impacting growth-promoting pathways
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Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet
Skipping doses or discontinuing treatment prematurely may affect the desired outcomes
AOD-9604 progressed through six human clinical trials with more than 900 participants but failed to reach statistical significance in its Phase IIb obesity endpoint, and Metabolic Pharmaceuticals terminated development in 2007
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