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Diabetic ketoacidosis In patients with insulindependent diabetes, the risk of DKA is the primary concern
Aromatase inhibitors are available if needed but are used conservatively some estrogen is necessary for bone and cardiovascular health
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Bridging the efficacy gap: Clinical trials often include motivated patients with regular support
Furthermore, an extra supplement of SCFAs could prevent cardiorenal lipotoxicity and glucometabolic dysregulation by suppressing UA accumulation (191)
Originally developed for treatment of type 2 diabetes in 2004, and later approved for weight loss in 2014, GLP-1s have demonstrated clinically meaningful reductions in A1c as well as unprecedented weight loss, with patients losing up to 20% of t heir body weight. There has been rapid adoption and a surge in demand for incretin-based therapies
