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The dosing window is short

But topical absorption remains variable and may require higher concentrations for systemic effects

In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [2]

Trial data have shown weight reductions of up to approximately 22% in clinical studies

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