b , Structure comparison of SLC33A1 in the presence of GSSG or acetyl-CoA shows partial overlap in residues proximal to the bound ligands, including Y225 and Y418
YamanakaGSuzukiSTakeshitaMGoSMorishitaNTakamatsuTet al
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Ciftci, D
Neither, in general, can reversed-phase HPLC purity: disulfide isomers can co-elute, and even when they separate, an area-percent figure at a single wavelength tells you the peaks are different, not which peak is the folded protein