However, prolonged or excessive shedding (lasting more than 4-6 weeks or resulting in visible thinning) suggests problems rather than transition
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Poorly organised collagen, the kind typically deposited in avascular healing, is mechanically inferior
PTD-DBM is applied topically, limiting its effects to the treatment site
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As the sweat evaporates from the skin surface into the surrounding air, it takes heat with it (ie evaporative cooling)