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First, FDA-approved products have the most consistent supply, the cleanest insurance-coverage path if a covered indication later applies, and the most extensive post-market safety data relevant for a population with higher comorbidity rates and more concurrent medications

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R.BarbieriM.PaolissoP.D'OnofrioN.GiovaneA.et al (2015)

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Some patients take GLP-1 medication long-term as part of ongoing chronic disease management, while others may be able to taper off after reaching their goals particularly if they've built strong nutritional and behavioral habits during treatment