tirzepatide and crohn's Patients with stable inflammatory bowel disease (IBD) comorbid obesity and/or diabetes who started GLP-1 receptor agonists (semaglutide or tirzepatide) alongside ongoing treatment did not have a lower risk for the relapse GLP-1 Use in Crohn's Disease:

The peptides and small molecules under development elicit weight loss by mimicking amylin, a naturally occurring hormone that plays a role in glucose regulation

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Overweight and obesity in adults NHS