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In one phase 2 trial of people with obesity, some of whom also had type 2 diabetes, participants lost 20.5% of their fat mass while increasin g their lean muscle mass by 3.6% over 48 weeks of treatment
A reduced risk of CRC was reported in a retrospective study of over 1 million individuals with type 2 diabetes (T2D) 45
Structure of an endosomal signaling GPCRG protein-arrestin megacomplex
Obesity so dramatically decreases ones lifespanreducing life expectancy as much as a decade, that these GLP-1 drugslike bariatric surgeryshould be considered as a last resort for those unwilling or unable to treat the cause of their obesity
So the combination appears to deliver benefits well beyond body weight alone
Deliberate protein targeting of 0.7-1.0 grams per pound of goal body weight helps preserve lean mass during rapid weight loss
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