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If gastrointestinal symptoms are severe or persistent, delaying dose escalation or temporarily reducing the dose may be appropriate, as guided by the prescribing healthcare provider

You could dose up without having that peak-trough kind of saw-toothing, which causes GI distress and made the drugs intolerable without a very flat profile

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Some hypothyroidism symptoms like fatigue, low mood, or muscle aches can make exercise more challenging, so start slowly and build up at your comfort level

With diverticulitis, on the other hand, you will most likely experience notable symptoms

This risk has not been confirmed in humans