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An easy way to conceptualize this system is as though there were an on and off switch for pain

10.1186/s43159-022-00189-w 34

10.1016/j.bbamcr.2012.05.002 42 EspayA

10 , e020734 (2021)

This process is particularly pronounced when glutathione (GSH) is depleted or glutathione peroxidase 4 (GPX4), a key enzyme that prevents lipid oxidation, is inhibited [39]