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A 2020 preclinical safety evaluation (Xu et al., 2020, Regul Toxicol Pharmacol ) confirmed a favorable profile at research-relevant doses with no significant organ toxicity at tested concentrations

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Dosage and administration Typical protocols in the literature and clinical practice use subcutaneous injection , often run in a loading-then-maintenance pattern: a higher loading dose over the first 46 weeks, then a lower maintenance dose