Uses / Potential Benefits (Research / Translational) Muscular and tendon injury recovery studies Inflammation and joint health research Wound and tissue regeneration models Vascular and cellular repair investigations Safety / Side Effects / Cautions Limited clinical data
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doi:10.1038/nsb0498-267
Subsequent studies have consistently supported the finding of widespread RCD, activated via the intrinsic apoptotic pathway, which includes concurrent elevation of capsase-9, cytochrome C, BAX, and a decrease in anti-apoptotic BCL2, in rat (63, 85, 89, 114, 116, 125, 134, 138142), mouse (62, 113, 117, 143) and NHP (137, 144147) models, with both in vitro (62, 85, 113, 114, 116, 139, 140) and in vivo (62, 63, 116, 117, 125, 134, 138, 141143) experimental protocols