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Within the PVN, GLP-1 influences feeding behavior by modulating postsynaptic membrane excitability, likely mediated through the AC-cAMP-PKA pathway (Fig

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Stuber and Wise, 2016) but repeated exposure to such foods can profoundly reshape function of such brain circuits that further promote the intake of these calorie dense foods at the expense of less palatable, lower calorie foods that offer an overall superior nutritional profile (Wang et al., 2001