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Comparing Side Effects, Safety, and Cost When comparing Mounjaro (tirzepatide) and Wegovy (semaglutide), its important to look beyond weight loss outcomes and consider tolerability, safety, and affordability
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Historically, this increased insulin response mediated by GLP-1 and GIP had been attributed to factors termed incretins (derived from incretion, a term used at that time to refer to a secretion that remains inside the body), hence the name incretin effect is still used today to describe the rise in insulin mediated by the action of these hormones
A 2025 systematic review and meta-analysis of 18 randomized trials involving 3,771 participants found that after GLP-1 receptor agonist discontinuation in obesity, average rebound included +5.63 kg body weight, +0.25% HbA1c, plus worsening in waist circumference, BMI, systolic blood pressure, and fasting plasma glucose