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It often supplements (rather than replaces) other therapies
The statistical analyses were performed using Prism9 GraphPad and generally included a ROUT outlier analysis
10.1289/ehp11813
10.1515/BC.2009.033 Biol Chem
The free energy of a typical reaction is calculated directly from its E o by the Nernst equation as shown below, where n is the number of electrons involved in the reaction and F is the Faraday constant (23.06 kcal/volt/mol or 94.4 kJ/volt/mol): G = nF E o For the oxidation of NADH, the standard biological reduction potential is 52.6 kcal/mole
This feed-forward mechanism is particularly damaging for dopaminergic neurons as their already high metabolic burden makes them unable to withstand this additional loss of GSH, resulting in apoptosis (Gabby et al., 1996)
