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In high-income nations with established diabetes care systems, GLP-1 receptor agonists exhibit advantageous cost-effectiveness ratios when accounting for cardiovascular and renal protective benefits, with incremental cost-effectiveness ratios generally falling below $50,000 per quality-adjusted life year (QALY) for high-risk patients (Kong et al
It has a relatively short half-life, a strong ability to delay gastric emptying, and an affinity for GLP-1 receptor that is four times that of natural GLP-1
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In future RCTs, key considerations such as the optimal timing of intervention, treatment duration, specific patient subgroups based on molecular diagnosis, and potential systemic adverse events require further investigation
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