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At least 3 non-consecutive, well-oriented tissue sections per mouse were used for quantification

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Le Douce, J

These symptoms tend to develop gradually however they can worsen if left untreated

However, on average, people can lose at least 15% of their weight and are able to maintain these results for 2 years until they hit a plateau

Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss