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On the contrary, -KG can be converted into glutamine through glutamate dehydrogenase (GDH) and glutamine synthetase (GS), or into CO 2 through the TCA cycle to provide energy to cells (58)
1,5 ( 2 .) 2
[2] This may stimulate the production of second messengers like cAMP and IP3 (inositol trisphosphate), which could propagate the signal within the cell and possibly activate protein kinases that may phosphorylate target proteins and regulate cellular processes
Breaking this cycle is a primary goal in functional management strategies for MCAS and related neuroimmune conditions
doi:10.2337/db22-823-P
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