However, using compounded GLP-1s carries specific risks: Lack of rigorous testing: Compounded medications are not FDA-approved and have not undergone the same rigorous testing for safety and effectiveness as brand-name drugs
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For a patient dealing with early nausea, persistent constipation, or symptoms that return after a treatment change, an individualized review may consider medical history, current medications, symptom severity, hydration, food intake, previous gastrointestinal concerns, and overall treatment goals
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Some clinicians use it off-label for older adults or perimenopausal patients struggling specifically with abdominal fat that has not responded to diet, exercise, or GLP-1 therapy alone