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[1] [3] Some medications, such as chloramphenicol, may interact with B12 therapy

FDAs 2024 review summarized several early human studies and the later OPTIONS study

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0, 3M, 6M, 9M, 12M, 18M, 24M (long-term) Accelerated Stability Data (40C/75% RH) Long-term Stability Data (25C/60% RH) Photostability (ICH Q1B) Stability Conclusion: (40C/75%RH)(25C/60%RH) 24 2-8C, protect from light Product remains within specification under both accelerated and long-term conditions