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The radio-resistance of CSCs is associated with their low proteasome activity, which reduces the proteasome-dependent degradation of antioxidant-related molecules such as xCT, Nrf2, and ATF4, thereby leading to their intracellular accumulation 18,19,20 The cystine/glutamate antiporter xCT, also known as SLC7A11, is involved in GSH biosynthesis and maintains tumor redox status 21 In addition, the accumulation of transcription factors including Nrf2 and ATF4 promotes xCT expression, enhancing the cellular antioxidant capacity 19
That is a net difference of 42 square centimeters