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Effect of body mass index on treatment response of biologic/targeted-synthetic DMARDs in patients with rheumatoid arthritis, psoriatic arthritis or axial spondyloarthritis
It also acts as a skin conditioning agent
Evans JM, Ogston SA, Emslie-Stnith A, Morris AD: Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin
2021 Oct;290(4):826-854
The TRANSCEND-T2D-1 trial (diabetes-specific) confirmed 16.8% weight loss and 2.0% HbA1c reduction at 40 weeks
The theoretical oncogenic risk is a significant unresolved safety question for any long-term human application
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