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These reference points come from preclinical literature and small pilots
MDS1-EVI1 Complex (MECOM) Activation Promotes Leukemic Stem Cell Quiscence By Upregulating CDKN1C/P57Kip2
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As an antioxidant, it could potentially reduce the effectiveness of some chemotherapy drugs that rely on the generation of free radicals to kill cancer cells
Moreover, these multi-protein complexes are continuously exposed to a GSH-depleted environment in Gclc -deficient FoB, which might alter protein folding or their targeting to the mitochondria
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