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A systematic review of 76 different clinical trials looking at the risk of gallbladder disease for people taking GLP-1 agonists showed that there was an increase in risk for the development of gallbladder disease when taken at higher doses for long periods of time
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In controlled trials, pancreatitis rates in GLP-1 groups ranged from 0.1% to 1.2% , with placebo groups reporting similar numbers
Doctors have been prescribing GLP-1s to treat type 2 diabetes for two decades, but the drugs were approved for weight loss in 2014
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