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This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]

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Redox modulation of N -methyl-d-aspartate-stimulated neurotransmitter release from rat brain slices

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Additionally, hypersensitivity reactions occurred in approximately 2-4% of participants