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Interestingly, it was reported that inhibitors of glutamate carboxypeptidase II (enzyme that inactivates N -acetylaspartylglutamate) are useful in rescuing memory impairments in rodent models of neurogenerative disorders [100], as well as preventing increases in glutamate release induced by the NMDA receptor non-competitive antagonist phencyclidine, through NAAG actions on mGluR3 [99]

[12] En un ambiente oxidante, se forman puentes disulfuro intermoleculares, y la enzima cambia al estado dimrico activo

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Another strategy is to adjust patients diets and lifestyles, such as adopting low-sugar diets or increasing physical activity, to positively affect metabolic health