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The crude material was purified by Isolera flash column chromatography on silica via gradient elution, from 100% dichloromethane to 15% methanol in dichloromethane to produce CAM-S-CAM-TPP (9.1 mg, 16%) as a pale yellow fluffy/foamy solid

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648 Preclinical studies have shown that MSC transplantation improves nerve function and reduces neuropathic pain in diabetic animal models 649