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Chronic inflammation is the driving force for the onset and progression of fibrosis in NASH (61)

10.3389/fimmu.2020.579220 Front Immunol

Thus, abnormal estrogen metabolism, which results in increased E2 levels, may contribute to a higher occurrence of GD

Upon exposure to these inducers, plants rapidly activate their intrinsic immune defense mechanisms to induce systemic acquired resistance (SAR) throughout the entire plant, thereby enhancing its immunity resistance against pathogen invasion [9,10,11]

This type of medication-induced pigmentation might be seen in children with cancer who are receiving certain chemotherapeutic agents or in HIV positive children being treated with AZT