Quick Takeaways Retatrutide is a triple-receptor agonist (GLP-1, GIP, glucagon) delivering superior monotherapy weight loss at 2428.7% over 4868 weeks Cagrilintide targets amylin receptors for satiety and gastric emptying, achieving 10.8% weight loss in 26 weeks as a monotherapy Retatrutide provides broader metabolic benefits, including dramatic improvements in HbA1c, blood pressure, waist circumference, insulin sensitivity, and liver fat normalization No head-to-head trials exist yet, but the mechanistic and clinical data strongly favor Retatrutide for total body recomposition Retatrutide vs Cagrilintide: Side-by-Side Comparison What Makes Retatrutide Different Retatrutide isnt just another GLP-1 receptor agonist
Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riesmeyer JS, Riddle MC, Rydn L, et al
Products marketed as "GLP-1 patches" do not contain GLP-1 receptor agonists regardless of marketing terminology
(comment updated 4/26) Why is "Sip Til Send" not currently recommended
Peptide and supplement stacks : Whats being combined, and why, for (i) muscle gain, (ii) fat loss, and (iii) insulin sensitivity
Add one peptide, evaluate for 2 to 4 weeks, then consider adding another