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P = 0.02), and fasting blood glucose (MD = -0.21
A sensitivity analysis excluding the ITCA trial reported a similar reduction in MACE as the pooled analysis (HR (95%CI): 0.86 (0.810.90)
Some RCTs have also reported beneficial effects of combining vitamin D with magnesium, zinc, vitamin K, and vitamin E, showing improvements in hormonal balance, inflammation, and oxidative stress
Specifically, the ELIXA (lixisenatide) trial studied patients with T2DM who had recent acute coronary syndrome and found that the addition of lixisenatide to conventional therapy did not result in a significant difference in cardiovascular endpoints relative to placebo (Table 1) [56]
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