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Wegovy, a separate Novo Nordisk product that also contains semaglutide, is FDA-approved for specified weight-management indications - the two are not interchangeable, and only one is approved for weight management
Delayed gastric emptying leaves food and liquid in the stomach longer, increasing stretch and chemical stimulus to visceral afferents that communicate with the brainstem nausea centers
The SURMOUNT-4 trial demonstrated that patients who stopped tirzepatide after achieving weight loss regained approximately 14% of body weight over 52 weeks, while those continuing treatment maintained their loss
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Notably, after a 4-week washout period these beneficial effects diminished, with the exception of clinical severity scores
The left hind limbs were shaved and hair removal cream was used in order to remove all the fine fur
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