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Less common systemic effects include mild lightheadedness (possibly copper-related), temporary headache, and occasional mild fatigue

GLP-1 agonists commonly cause nausea, vomiting, and gastrointestinal distress, particularly during dose escalation

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Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)