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This is a potentially life-threatening allergic reaction: if you experience hives, rapid heartbeat, swelling (face, tongue, and/or throat), or shortness of breath after taking milk thistle or milk thistle supplements then seek immediate emergency help

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J Mol Neurosci (2002) 18:714

The most common side effects are gastrointestinal, including nausea (affecting 2040% initially), vomiting, diarrhoea, and constipation

Proc Natl Acad Sci USA 112 , 82608265, (2015)