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Through promoting lipolysis in adipose tissue, IR is believed to exacerbate lipotoxicity, which is positive feedback further aggravating the imbalance of metabolism (121)
Implications for telehealth companies and weight loss drug sellers: If its true that so few Hims members are using compounded GLP-1s, its unclear why the company pushed to keep offering them rather than secure branded distribution deals with Novo or Eli Lillymoves that likely would have left it far more stable than it is now (stock down ~54% YTD)
and J.C.D
Gender-based considerations The phase 2 trial included both men and women, and the results did not show statistically significant differences in weight loss between genders at matched doses
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It builds on the earlier TRIUMPH-4 knee OA signal (a ~76% reduction reported in December 2025) and confirms the effect replicates in a second, larger cohort
