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In multiple animal and in-vitro studies, both peptides have demonstrated high tolerability and absence of systemic toxicity

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The lipid tail allows retatrutide to bind serum albumin, which slows clearance and gives the peptide a half-life long enough for once-weekly dosing in published animal pharmacokinetic work

Growth hormone is a potent driver of lipolysis (fat breakdown) and supports muscle protein synthesis, satellite cell activation, and lean mass maintenance (11)