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Patients who haven't responded well to other GLP-1 medications, or who have a significant amount of weight to lose and want the strongest average efficacy available, are often good candidates for tirzepatide

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Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

For example, a number of large-scale clinical trials have demonstrated that GLP-1RA could reduce the risk of cardiovascular events, which has been well reviewed in elsewhere (83, 84) and we will not further discuss here

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