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Buyer Takeaway 10: The published evidence points toward a four-part musculoskeletal protection strategy during GLP-1 therapy: baseline DXA measurement, resistance training at least twice weekly, adequate protein at every meal, and appropriate calcium/vitamin D
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A minimum of four weeks is recommended at any dose level before increasing
For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg
Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents
Antioxidants (Basel) 12(2):470
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