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Unlike the C-terminal amide of Melanotan II, the free carboxylate here is titratable and carries an additional negative charge at neutral pH, so record buffer pH alongside concentration when comparing the two molecules in the same assay

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It has been suggested that phase II conjugation stabilizes the molecule and that conjugates represent carriers for the transport in circulation (42, 89, 90)

2025;DOI: 10.1002/art.43403

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