Memisogullari R et al reported that glutathione peroxidase activity was significantly decreased in type II diabetes mellitus
Also specific bitter herbs such as St Mary's Thistle, Andrographis, Dandelion, Golden Seal, Angelica Root and Gentain
For example, a fact that the formation of protein corona on anti-HER2 antibody-functionalized lipid nanocarriers led to a significant reduction in cellular uptake by HER2 +ve breast cancer cells, which resulted in compromised targeting capability, has been established by the study conducted by Marchal et al
Note that a 200 mg dose is 1.0 mL a relatively large subcutaneous volume
What could be the cause
NAD+ helps produce NADPH (the energy that keeps Glutathione active), while Glutathione helps reduce oxidative stress, which protects and preserves NAD+