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Chromatographic separation was performed on a Waters Acquity CORTECS C18 + column using a mixture of acetonitrile and water acidified with 0.1% formic acid

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Because Ozempic slows gastric emptying, the absorption of caffeine may be delayed, so its effects could last longer or feel different

This temporary disruption typically resolves as your system adjusts, but practical strategies can ease the transition: maintain consistent sleep and wake times, avoid large meals within 3 hours of bedtime (already easier on GLP-1), and limit screen time 30 minutes before sleep